Overview

The science of personalized value development through adolescence: integration of brain, real-world, and life-course approaches

Principal Investigator: Kiyoto Kasai, M.D., Ph.D.
(Professor, Department of Neuropsychiatry, The University of Tokyo)

Purpose of the Research Project

Our project aims at establishing an interdisciplinary scientific field that will be dedicated to the development of "personalized value" through adolescence by integrating brain, real-world, and life-course approaches.

Human adolescence is far longer than that in non-human primates and is the life stage in which the cerebral neocortex matures. While childhood is associated with trans-generational incorporation of parental values, adolescence is characterized by social interactions with peers. Through such influences, a person's value is internalized and personalized to become "personalized value".

Content of the Research Project

A01 aims at uncovering the neural basis of personalized value. Here, value development can be modeled as the psychological process in which adolescents acquire the ability to control the conflict between value memory and actual behavior by using self-regulation, including meta-cognition and language (inner-speech).

B01 considers the "real-world" as a modulatory factor in the neural basis of value development. Here, we propose a spiral model where active interactions with the real-world influence value development, which then shapes patterns of action in life, in turn inducing plasticity in the brain circuit.

C01 will use life-course epidemiology to understand how personalized value is developed in adolescence and how it influences later life. The Tokyo TEEN Cohort will be the main studied population.

By integrating brain (A01), real-world (B01), and life-course (C01) approaches, D01 will deepen the conceptual framework of personalized value. We will then develop psychosocial intervention strategies to evolve personalized value.

Expected Research Achievements and Scientific Significance

Our project will propose a new interdisciplinary science of the "action brain", where we clarify how the brain evolves personalized value through adolescence to actively influence the social environment and pursue subjective well-being. Our findings will ultimately contribute to policy-making concerning education and health promotion in adolescence.

Key Words

Adolescence: a developmental stage from the onset of puberty through maturation of the neocortex.
Personalized value: a person's inner drive for long-term action, which will be internalized and personalized through adolescence.

Research Organization/Members

Principal investigator

  • Kiyoto Kasai
    The University of Tokyo Graduate School of Medicine Psychiatry
    Neuroimaging

International Advisory Board

  • Marcus Richards
    Marcus Richards
    MRC Unit for Lifelong Health and Ageing,
    MRC National Survey for Health and Development,
    Medical Research Council
    Cognitive Epidemiology
  • Louise Arseneault
    Louise Arseneault
    the Institute of Psychiatry,Psychology and Neuroscience
    at King’s College London
    Biomedical Science,
    developmental psychology
    and epidemiology
  • Elaine F. Walker
    Elaine F. Walker
    Samuel Candler Dobbs Professor of Psychology and Neuroscience
    Department of Psychology, Emory University
    Psychology,
    Neuroscience
  • Nicholas B. Allen
    Nicholas B. Allen
    Ann Swindells Professor of Clinical Psychology
    Department of Psychology
    University of Oregon
    Clinical psychology,
    Cinical Neuropsychology
  • Iroise Dumontheil
    Iroise Dumontheil
    Reader (Associate Professor) in Cognitive Neuroscience,
    Department of Psychological Sciences, Birkbeck, University of London
    Neuroimaging
  • George Patton
    George Patton
    Centre for Adolescent, University of Melbourne
    Epidemiology,
    Adolescent Health
  • Russell Viner
    Russell Viner
    Adolescent Health, Institute of Child Health,
    Faculty of Population Health Sciences,
    University College London
    Global Health,
    Adolescent Health
  • Johan Ormel
    Johan Ormel
    Department of Psychiatry,
    University Medical Center Groningen,
    University of Groningen
    Psychiatric Epidemiology
  • Noriko Cable
    Noriko Cable
    International Centre for Life course Studies in Society and Health,
    Department of Epidemiology and Public Health,
    University College London
    Epidemiology and
    Public Health
  • Tomas Paus
    Tomas Paus
    Tanenbaum Chair in Population Neuroscience,
    Professor of Psychology and Psychiatry, University of Toronto,
    Canada, & Dr. John and Consuela Phelan Scholar, Senior Scientist,
    Center for the Developing Brain, Child Mind Institute, New York, USA
    Population neuroscience,
    Psychiatry
  • Sheung-Tak Cheng
    Sheung-Tak Cheng
    Chair Professor of Psychology and Gerontology,
    The Education University of Hong Kong
    Positive psychology
  • Charles E. Irwin, Jr.
    Charles E. Irwin, Jr.
    Distinguished Professor of Pediatrics,
    Department of Pediatrics University of California,
    San Francisco School of Medicine
    Adolescent Medicine and
    Pediatrics
  • Trevor Robbins
    Trevor Robbins
    Professor of Cognitive Neuroscience and Experimental Psychology and Head
    Department of Psychology
    Behavioural and Clinical Neuroscience Institute
    University of Cambridge
    Cognitive and Behavioural Neuroscience
    Systems and Computational Neuroscience

Evaluation Committee members

  • Takashi Igarashi
    National Center for Child Health and Development
  • Emi Ikebuchi
    Graduate School of Medicine, Department of Psychiatry, Teikyo University
  • Masanobu Kanou
    Department of Neurophysiology, Division of Functional Biology, Graduate School of Medicine, The University of Tokyo
  • Toshikazu Hasegawa
    Graduate School of Arts and Sciences Department of Life Sciences, The University of Tokyo
  • Teruhiko Higuchi
    National Center of Neurology and Psychiatry

X00 Steering Committee members

Project Leader

  • Kiyoto Kasai
    Graduate School of Medicine, Department of Psychiatry, The University of Tokyo

Co-Researchers

  • Kohji Ishihara
    Graduate School of Arts and Science, The University of Tokyo
  • Syo Yagishita,Toshiya Murai,Ryu-ichiro Hashimoto,Takashi Sato,Eiji Aramaki,Masahiro Nochi,Yasumasa Okamoto,Miki Bundo
    Saori Tanaka,Mariko Hasegawa,Atsushi Nishida,Norito Kawakami,Masato Fukuda,Toshiaki Furukawa,Satoshi Usami

Y00 International Research Support Group

Project Leader

  • Kiyoto Kasai
    Graduate School of Medicine, Department of Psychiatry, The University of Tokyo

Co-Researchers

  • Saori Tanaka,Toshiya Murai,Atsushi Nishida,Mariko Hasegawa,Shuntaro Ando,Syudo Yamasaki,Shinsuke Koike
    Norito Kawakami,Shinsuke Kondo,Yuki Miyamoto

A01 Brain

Project Leader

  • Saori Tanaka
    Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International(ATR) ATR

Co-project Leaders

  • Ryu-ichiro Hashimoto
    Graduate School of Humanities, Tokyo Metropolitan University
  • Syo Yagishita
    Graduate School of Medicine, The University of Tokyo

Co-Researchers

  • Kazuo Okanoya
    Graduate School of Arts and Science, The University of Tokyo
  • Fumitaka Homae
    Graduate School of Humanities, Tokyo Metropolitan University
  • Shinsuke Koike
    Division for Counseling and Support,The University of Tokyo
    Graduate School of Arts and Sciences, The University of Tokyo

B01 Real-world

Project Leader

  • Toshiya Murai
    Graduate School of Medicine, Kyoto University

Co-project Leaders

  • Masato Fukuda
    Graduate School of Medicine, Gunma University
  • Takashi Sato
    National Instisute of Techonology, Okinawa College Department of Media Information Engineering

Co-Researchers

  • Takashi Hashimoto
    Japan Advanced Institute of Science and Technology School of Knowledge Science
  • Mariko Tada
    Graduate School of Medicine, The University of Tokyo

C01 Life-course

Project Leader

  • Atsushi Nishida
    Department of Psychiatry and Behavioral Science, Tokyo Metropolitan Institute of Medical Science
  • Co-project Leaders

    • Mariko Hasegawa
      School of Advanced Sciences, Graduate University for Advanced Studies
    • Norito Kawakami
      Graduate School of Medicine, The University of Tokyo

    Co-Researchers

    • Syudo Yamasaki
      Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
    • Shuntaro Ando
      Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
    • Satoshi Usami
      Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • Toshiaki Furukawa
      Graduate School of Medicine, Kyoto University
    • Yukiko Kano
      Graduate School of Medicine, The University of Tokyo
    • Tsuyoshi Okamura
      Graduate School of Medicine, The University of Tokyo
    • Ko Murayama
      Department of Psychology, University of Reading
      Research Organization, Kochi University of Technology

    D01 Evolving

    Project Leader

    • Kiyoto Kasai
      Graduate School of Medicine, The University of Tokyo

    Co-project Leaders

    • Yasumasa Okamoto
      Institute of Biomedical & Health Sciences, Hiroshima University
    • Masahiro Nochi
      Graduate School of Education, The University of Tokyo
    • Eiji Aramaki
      Institute of Research Initiatives, Nara Institute of Science and Technology
    • Miki Bundo
      Faculty of Life Sciences, Kumamoto University

    Co-Researchers

    • Shinsuke Kondo
      Graduate School of Medicine, The University of Tokyo
    • Yuki Miyamoto
      Graduate School of Medicine, The University of Tokyo
    • Hitoshi Kuwabara
      Disability Services Office, The University of Tokyo
    • Kayo Ichihashi
      Graduate School of Medicine, The University of Tokyo
    • Motomu Suga
      Graduate School of Medicine, The University of Tokyo
    • Shinichiro Kumagaya
      Research Center for Advanced Science and Technology, The University of Tokyo
    • Noriaki Yahata
      Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences
    • Kazuya Iwamoto
      Faculty of Life Sciences, Kumamoto University